血清中骨形态发生蛋白的放射免疫测定：骨代谢的组织特异性参数
Radioimmunoassay of bone morphogenetic protein in serum: a tissue-specific parameter of bone metabolism.
作者信息
Urist M R, Hudak R T
出版信息
Proc Soc Exp Biol Med. 1984 Sep;176(4):472-5. doi: 10.3181/00379727-176-41900.
PMID:6463058
Abstract
Bone morphogenetic protein (BMP), a paracrine agent inducing cartilage and bone cell differentiation, circulates in the blood and is detectable by BMP radioimmunoassay. Serum BMP levels are higher in growing children and patients with Paget's disease than in normal adults. These observations are interpreted as evidence of a BMP function in the physiology of bone in health and disease.
摘要
骨形态发生蛋白（BMP）是一种诱导软骨和骨细胞分化的旁分泌因子，在血液中循环，可通过BMP放射免疫测定法检测到。生长中的儿童和佩吉特病患者的血清BMP水平高于正常成年人。这些观察结果被解释为BMP在健康和疾病状态下骨骼生理学中发挥作用的证据。
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