McLachlan R S, Gloor P, Avoli M
Brain Res. 1984 Jul 30;307(1-2):277-87. doi: 10.1016/0006-8993(84)90481-5.
Extracellular single unit and electroencephalographic (EEG) activity during generalized spike and wave discharges (SW) induced by i.m. penicillin was recorded simultaneously in the cortex, in a 'specific' thalamic nucleus (n. lateralis posterior, LP) and in some 'non-specific' thalamic nuclei (n. centralis medialis, NCM; n. centrum medianum, CM; n. centralis lateralis, CL) Computer-generated EEG averages and histograms of single unit activity were triggered by either peaks of EEG transients or action potentials. The time at which cortical neurons (66/66) were most likely to fire was during the 'spike' of the SW complex while absence of firing was the rule during the 'wave'. Most LP neurons (23/26) showed a similar pattern, 3 cells firing preferentially during the 'wave'. In NCM only 17 of 39 neurons fired during the 'spike', 8 of 39 neurons during the 'wave' while the others showed no change in their firing pattern during SWs. Twenty-six of 30 CM and 20 of 24 CL neurons fired during the 'spike' of SW; the other cells in these nuclei did not change their firing pattern during SWs. When present, rhythmic fluctuations in firing linked to SW discharge were less prominent in these 'non-specific' thalamic nuclei than in cortex and LP. Furthermore, participation of NCM, CM and CL neurons in the SW rhythm occurred only after neurons in cortex and LP had become involved in it. Thus, as is the case for cortical neurons, the main firing pattern of thalamic cells during SWs consists of an oscillation between 'excitation' during the 'spike' and 'inhibition' during the 'wave' of the SW complex. However, the coupling between cortical and thalamic neuronal firing is less intimate for cells of the 'non-specific' thalamic nuclei than for a 'specific' nucleus such as LP. Thus, at least some 'specific' thalamic nuclei are more intimately involved in the mechanism of SW discharge than the midline intralaminar nuclei.
在肌肉注射青霉素诱导的全身性棘波和慢波放电（SW）期间，同时记录皮质、一个“特异性”丘脑核（后外侧核，LP）和一些“非特异性”丘脑核（内侧中央核，NCM；中央中核，CM；外侧中央核，CL）的细胞外单单位活动和脑电图（EEG）活动。通过EEG瞬变峰值或动作电位触发计算机生成的EEG平均值和单单位活动直方图。皮质神经元（66/66）最可能放电的时间是在SW复合波的“棘波”期间，而在“慢波”期间则通常不放电。大多数LP神经元（23/26）表现出类似的模式，3个细胞在“慢波”期间优先放电。在NCM中，39个神经元中只有17个在“棘波”期间放电，39个神经元中有8个在“慢波”期间放电，而其他神经元在SW放电期间其放电模式没有变化。30个CM神经元中的26个和24个CL神经元中的20个在SW的“棘波”期间放电；这些核中的其他细胞在SW放电期间其放电模式没有变化。当存在时，与SW放电相关的放电节律波动在这些“非特异性”丘脑核中不如在皮质和LP中明显。此外，NCM、CM和CL神经元参与SW节律仅在皮质和LP中的神经元参与之后。因此，与皮质神经元一样，丘脑细胞在SW放电期间的主要放电模式是在SW复合波的“棘波”期间的“兴奋”和“慢波”期间的“抑制”之间的振荡。然而，与“特异性”核如LP相比，“非特异性”丘脑核细胞的皮质和丘脑神经元放电之间的耦合不那么紧密。因此，至少一些“特异性”丘脑核比中线板内核更密切地参与SW放电机制。
