Reske S N, Schön S, Knust E J, Machulla H J, Eichelkraut W, Hahn N, Winkler C
Nuklearmedizin. 1984 Apr;23(2):83-5.
In 8 pentobarbital-anesthetized mongrel dogs the correlation between regional myocardial blood flow (RMBF) and regional cardiac uptake of 15-(p-123I-phenyl)-pentadecanoic acid (IPPA) was determined. Three animals were studied under control conditions, in three dogs an acute ischemia was produced by LAD ligation, and two dogs were paced at 195 beats/min. RMBF values were 20-50 ml/min X 100 g in acutely ischemic myocardium. 90-120 ml/min X 100 g under normal conditions and 200-250 ml/min X 100 g during pacing-induced stimulation. Total cardiac uptake of IPPA was 4.5-6% of the injected dose. In normal and acutely ischemic myocardium a good correlation between RMBF and IPPA uptake was obtained. Under stimulated conditions only a moderate increase of IPPA accumulation was found. At RMBF values above 150-170 ml/min X 100 g an upper limit of IPPA uptake was observed and can be explained by limited diffusion or an increased utilization of alternative substrates.
在8只戊巴比妥麻醉的杂种犬中，测定了局部心肌血流量（RMBF）与15-（对-123I-苯基）-十五烷酸（IPPA）的局部心脏摄取之间的相关性。三只动物在对照条件下进行研究，三只犬通过结扎左前降支产生急性缺血，两只犬以195次/分钟的频率起搏。急性缺血心肌的RMBF值为20 - 50毫升/分钟×100克。正常条件下为90 - 120毫升/分钟×100克，起搏诱导刺激时为200 - 250毫升/分钟×100克。IPPA的总心脏摄取量为注射剂量的4.5 - 6%。在正常和急性缺血心肌中，RMBF与IPPA摄取之间存在良好的相关性。在刺激条件下，仅发现IPPA积累有适度增加。在RMBF值高于150 - 170毫升/分钟×100克时，观察到IPPA摄取的上限，这可以用有限的扩散或替代底物利用增加来解释。
