Azpiroz F, Malagelada J R
Am J Physiol. 1984 Sep;247(3 Pt 1):G265-72. doi: 10.1152/ajpgi.1984.247.3.G265.
The stomach accommodates to distension with a minimal rise in intragastric pressure, but the effects of gastric accommodation on overall gut motor activity are unknown. In four conscious fasted dogs, constant gastric distension (0, 10, 20, 40, 80, 160, 320, and 640 ml) was produced by an air-filled intragastric bag; intrabag and gastrointestinal pressure activities (fundus, antrum, and proximal intestine) were recorded for 4 h. With the bag empty (or without bag), the proximal stomach exhibited a fasting cyclic motor pattern synchronized with that in the antrum and upper intestine. During periods of activity the fundus generated powerful phasic pressure waves. Increasing intrabag volumes up to 80 ml gradually lengthened phase II of the intestinal interdigestive motor cycle. At 160 ml or more, gut cyclic motor activity disappeared and was replaced by continuous irregular activity, although the intrabag pressure increased to less than 7 mmHg. We concluded that gastric distension markedly alters gut motor activity even though gastric accommodation prevents a major increase in intragastric pressure.
胃能够适应扩张，而胃内压的升高幅度极小，但胃容受性对整个肠道运动活动的影响尚不清楚。在4只清醒禁食的狗身上，通过一个充气囊产生持续的胃扩张（0、10、20、40、80、160、320和640毫升）；记录囊内及胃肠道压力活动（胃底、胃窦和近端肠道）4小时。当气囊为空（或无气囊）时，近端胃呈现出与胃窦和上段肠道同步的禁食周期性运动模式。在活动期，胃底产生强烈的阶段性压力波。将囊内体积增加至80毫升时，肠道消化间期运动周期的II期逐渐延长。当达到160毫升或更多时，肠道周期性运动活动消失，取而代之的是持续的不规则活动，尽管囊内压力增加至小于7毫米汞柱。我们得出结论，尽管胃容受性可防止胃内压大幅升高，但胃扩张仍会显著改变肠道运动活动。
