Moraes-Silva M A, Andrade R R, Oliveira R A, Spadaro J, Curi P R, Hossne W S
Braz J Med Biol Res. 1984;17(1):75-82.
The effects of dopamine infusion (10 and 20 micrograms kg-1 min-1) on pulmonary arterial pressure (PAP) and pulmonary arterial resistance (PAR) were studied. Experiments were carried out on 60 anesthetized dogs using two different models: model A, with mechanical perfusion of pulmonary circulation and constant left ventricular output, and model B, with physiologic pulmonary perfusion and non-fixed ventricular output. When pulmonary blood flow was constant, dopamine did not change PAP or PAR at either dose. When cardiac output (CO) was allowed to increase, PAP increased with dopamine at both doses, whereas PAR did not change with 20 micrograms kg-1 min-1 dopamine and was reduced by the 10 micrograms kg-1 min-1 dose. We conclude that the increase in PAP could not be explained solely by the rise in CO, but was probably related to an inhibitory effect of dopamine on pulmonary vascular accommodation and to increases in CO, especially when the drug was utilized at higher doses.
研究了多巴胺输注（10和20微克/千克·分钟）对肺动脉压（PAP）和肺动脉阻力（PAR）的影响。使用两种不同模型对60只麻醉犬进行了实验：模型A，采用肺循环机械灌注且左心室输出恒定；模型B，采用生理性肺灌注且心室输出不固定。当肺血流量恒定时，两种剂量的多巴胺均未改变PAP或PAR。当允许心输出量（CO）增加时，两种剂量的多巴胺均可使PAP升高，而20微克/千克·分钟剂量的多巴胺未改变PAR，10微克/千克·分钟剂量的多巴胺使PAR降低。我们得出结论，PAP的升高不能仅由CO的升高来解释，而可能与多巴胺对肺血管调节的抑制作用以及CO的增加有关，尤其是在使用较高剂量药物时。
