Preuss H G, Slemmer Gaydos D, Singh Aujla M, Areas J, Vertuno L L
Ren Physiol. 1984;7(5):321-8. doi: 10.1159/000172952.
Renal slices from 191 rats in various states of acid-base balance were investigated for their ability to produce ammonia from both glutamine and glutamate. Under a variety of conditions, in three different type studies, a significantly similar correlation existed between ammonia adaptation from glutamine and glutamate. This relationship was maintained during acute and chronic acidosis and during alkalotic inhibition of renal ammoniagenesis. We conclude from our findings that ammonia adaptation in rats secondary to acute and chronic acidosis is similar, although incomplete during acute acidosis. Our results further support the hypothesis that the rate of glutamate deamination is a major mechanism for overall renal ammonia adaptation in rats during acid-base changes.
对191只处于不同酸碱平衡状态的大鼠的肾切片进行了研究，以考察其从谷氨酰胺和谷氨酸生成氨的能力。在各种条件下，通过三项不同类型的研究发现，从谷氨酰胺生成氨和从谷氨酸生成氨之间存在显著相似的相关性。这种关系在急性和慢性酸中毒期间以及肾氨生成的碱中毒抑制期间均保持。我们从研究结果得出结论，急性和慢性酸中毒继发的大鼠氨适应性相似，尽管在急性酸中毒期间并不完全。我们的结果进一步支持了以下假设，即谷氨酸脱氨速率是大鼠在酸碱变化期间总体肾氨适应性的主要机制。
