Simon J, Rosselin G
Horm Metab Res. 1978 Mar;10(2):93-8. doi: 10.1055/s-0028-1093450.
Insulin release was studied in vivo in the chicken using the radioimmunoassay previously described (Simon, Freychet and Rosselin 1974). An orally administered glucose load (2 g/kg b.w.) stimulated insulin release and was rapidly metabolized. A prolonged fasting period (65 hr) increased both initial plasma glucose and initial plasma insulin levels and highly impaired the glucose tolerance. A fasting-impaired insulin release and/or a fasting tissue "insulin resistance" accounted for this fasting-impaired glucose tolerance. An orally administered amino acid mixture (1 g/kg b.w.) stimulated insulin release to a very low extent. The effect was however sufficient to decrease the plasma glucose level. In combination with glucose, the oral amino acid load potentiated the effect of a dose of glucose on insulin release and highly improved the glucose tolerance. This synergism was still observed with the intake of a mixed and balanced diet. Therefore, except for some characteristics observed in the chicken which are discussed, the insulin regulation and the pancreatic beta-cell function are qualitatively similar in the chicken and in mammals.
采用先前描述的放射免疫分析法（Simon、Freychet和Rosselin，1974年）对鸡体内的胰岛素释放进行了研究。口服葡萄糖负荷（2克/千克体重）可刺激胰岛素释放，且葡萄糖迅速被代谢。长时间禁食（65小时）会增加初始血浆葡萄糖水平和初始血浆胰岛素水平，并严重损害葡萄糖耐量。禁食导致的胰岛素释放受损和/或禁食组织的“胰岛素抵抗”是造成这种禁食导致葡萄糖耐量受损的原因。口服氨基酸混合物（1克/千克体重）对胰岛素释放的刺激程度非常低。然而，这种作用足以降低血浆葡萄糖水平。与葡萄糖同时服用时，口服氨基酸负荷增强了一定剂量葡萄糖对胰岛素释放的作用，并显著改善了葡萄糖耐量。在摄入混合均衡饮食时仍可观察到这种协同作用。因此，除了在鸡身上观察到的一些有待讨论的特征外，鸡和哺乳动物在胰岛素调节和胰腺β细胞功能方面在质量上是相似的。
