Larkin E C, Kimzey S L, Siler K
J Appl Physiol Respir Environ Exerc Physiol. 1978 May;44(5):710-7. doi: 10.1152/jappl.1978.44.5.710.
Normal and iron-deficient rats were exposed to 90% O2 at 760 Torr for 24 or 48 h. Erythrocyte response to hyperoxia was monitored by potassium (rubidium) influx studies, by storage stress, and by ultrastructural studies. Normal rat erythrocytes exhibited morphological changes and decrease of ouabain-sensitive potassium influx compared to unexposed controls. Both components of erythrocyte potassium influx were affected by iron deficiency. Erythrocytes from unexposed iron-deficient rats showed a 50% increase in ouabain-sensitive potassium influx compared to controls. Iron-deficient rats exposed to hyperoxia for 24 or 48 h, had erythrocytes with morphological changes. Erythrocytes of iron-deficient rats exposed for 24 h showed no influx change; those exposed for 48 h showed a decrease of ouabain-sensitive influx compared to erythrocytes of controls.
将正常大鼠和缺铁大鼠置于760托的90%氧气环境中24或48小时。通过钾（铷）流入研究、储存应激和超微结构研究来监测红细胞对高氧的反应。与未暴露的对照组相比，正常大鼠红细胞表现出形态变化和哇巴因敏感钾流入减少。红细胞钾流入的两个组成部分均受缺铁影响。与对照组相比，未暴露的缺铁大鼠的红细胞哇巴因敏感钾流入增加了50%。暴露于高氧环境24或48小时的缺铁大鼠的红细胞出现形态变化。暴露24小时的缺铁大鼠的红细胞流入无变化；暴露48小时的缺铁大鼠的红细胞与对照组相比，哇巴因敏感流入减少。
