地塞米松与他莫昔芬联合使用对雏鸡输卵管的雌激素样作用。

Estrogen-like effects of combined dexamethasone and tamoxifen in the chick oviduct.

作者信息

Gravanis A, Binart N, Robel P, Baulieu E E, Catelli M G

出版信息

Biochem Biophys Res Commun. 1984 Oct 15;124(1):57-62. doi: 10.1016/0006-291x(84)90915-x.

Abstract

The effects of dexamethasone alone on withdrawn chick oviduct weight, DNA, protein content and progesterone receptor concentration were barely detectable, whereas ovalbumin and conalbumin synthesis were increased. When dexamethasone and tamoxifen were combined, a marked increase of total proteins, including egg white proteins, DNA and wet weight occurred. Progesterone receptor also was increased. The most striking result was the stimulation of DNA polymerase-alpha activity by combined dexamethasone and tamoxifen, whereas either compound was completely ineffective.

摘要

单独使用地塞米松对雏鸡输卵管重量、DNA、蛋白质含量和孕酮受体浓度的影响几乎无法检测到，而卵清蛋白和伴清蛋白的合成却增加了。当地塞米松和他莫昔芬联合使用时，包括蛋清蛋白、DNA和湿重在内的总蛋白显著增加。孕酮受体也增加了。最显著的结果是地塞米松和他莫昔芬联合使用可刺激DNA聚合酶-α的活性，而单独使用这两种化合物时则完全无效。