Elston R C
Genetics. 1984 Nov;108(3):733-44. doi: 10.1093/genetics/108.3.733.
Previous maximum likelihood methods to analyze quantitative data on two inbred parental strains, their F1 and backcross generations are extended in three directions: (1) a method is suggested to transform the data to better satisfy the assumptions of normality and homoscedasticity; (2) the likelihoods are modified to allow for litter correlations and heteroscedasticity and (3) allowance is made for the incorporation of F2 data. The problem of making a choice among a set of simple genetic hypotheses is further discussed.
以往用于分析两个近交亲本菌株及其F1和回交世代定量数据的最大似然法在三个方向上得到了扩展:(1)提出了一种对数据进行转换的方法,以更好地满足正态性和同方差性假设;(2)对似然函数进行了修正,以考虑窝仔相关性和异方差性;(3)考虑纳入F2数据。进一步讨论了在一组简单遗传假设中进行选择的问题。