Silberstein E B, DeLong S, Cline J
J Nucl Med. 1984 Dec;25(12):1300-3.
To determine the clinical significance of splenic uptake in bone scintigraphy and functional asplenia on the radionuclide liver-spleen image, bone and spleen scintigrams of 38 patients with sickle cell disease were reviewed. Eighteen underwent bone and liver-spleen studies, 15 had only bone images, and five had only liver-spleen studies. Sixteen of 33 who had bone scintigraphy showed splenic uptake, but the frequency of homozygous sickle cell (SS) disease was not greater than heterozygous sickle cell disease (S-hetero) in this group. SS patients with splenic uptake of Tc-99m diphosphonate had significantly fewer painful crises of the abdomen and extremities, and fewer inpatient and outpatient hospital visits than SS patients whose bone imaging did not visualize the spleen. Functional asplenia on liver-spleen images (16 cases) was seen only in SS disease. One SS patient, age 8, still had a spleen capable of phagocytizing colloid.
为了确定骨闪烁显像中脾脏摄取的临床意义以及放射性核素肝脾显像上功能性无脾的情况，回顾了38例镰状细胞病患者的骨和脾脏闪烁图。18例患者进行了骨和肝脾检查，15例仅进行了骨显像，5例仅进行了肝脾检查。在33例进行骨闪烁显像的患者中，16例显示脾脏摄取，但该组中纯合子镰状细胞（SS）病的发生率并不高于杂合子镰状细胞病（S-杂合子）。与骨显像未显示脾脏的SS患者相比，Tc-99m二膦酸盐脾脏摄取的SS患者腹部和四肢的疼痛危象明显较少，住院和门诊就诊次数也较少。肝脾显像上的功能性无脾（16例）仅见于SS病。1例8岁的SS患者仍有一个能够吞噬胶体的脾脏。
