色胺在脑和脊髓中的分布与周转。

The distribution and turnover of tryptamine in the brain and spinal cord.

作者信息

Juorio A V, Durden D A

出版信息

Neurochem Res. 1984 Sep;9(9):1283-93. doi: 10.1007/BF00973040.

Abstract

Tryptamine levels have been determined in mouse brain regions and spinal cord and in rat spinal cord. They were; caudate nucleus 2.5 ng X g-1, hypothalamus less than 0.5 ng X g-1, hippocampus less than 0.7 ng X g-1, olfactory bulb less than 0.7 ng X g-1, olfactory tubercles less than 0.6 ng X g-1, brain stem less than 0.4 ng X g-1, cerebellum less than 1.0 ng X g-1, and the "rest" 0.9 ng X g-1. The mouse whole brain was found to have 0.5 ng X g-1, the mouse spinal cord 0.3 ng X g-1, and the rat spinal cord 0.3 ng X g-1. These concentrations increased rapidly to 22.8 ng X g-1, 14.2 ng X g-1, and 6.6 ng X g-1 respectively at 1 hr after 200 mg X kg-1 pargyline. The turnover rates and half lives of tryptamine in the mouse brain and spinal cord and rat spinal cord were estimated to be 0.14 nmol X g-1 X h-1 and 0.9 min; 0.054 nmol X g-1 X h-1 and 1.5 min and 0.04 nmol X g-1 X h-1 and 1.6 min respectively. The aromatic L-aminoacid decarboxylase inhibitors NSD 1034 and NSD 1055 reduced synthesis of tryptamine in controls and pargyline pretreated animals. Tryptophan increased the concentrations of mouse striatal tryptamine and 5-hydroxytryptamine and brain stem 5-hydroxyindole acetic acid. p-Chlorophenylalanine reduced formation of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid but did not change that of tryptamine.

摘要

已测定小鼠脑区、脊髓以及大鼠脊髓中的色胺水平。具体数值如下：尾状核2.5纳克×克⁻¹，下丘脑低于0.5纳克×克⁻¹，海马体低于0.7纳克×克⁻¹，嗅球低于0.7纳克×克⁻¹，嗅结节低于0.6纳克×克⁻¹，脑干低于0.4纳克×克⁻¹，小脑低于1.0纳克×克⁻¹，其余部分为0.9纳克×克⁻¹。发现小鼠全脑含0.5纳克×克⁻¹，小鼠脊髓含0.3纳克×克⁻¹，大鼠脊髓含0.3纳克×克⁻¹。给予200毫克×千克⁻¹优降宁1小时后，这些浓度分别迅速升至22.8纳克×克⁻¹、14.2纳克×克⁻¹和6.6纳克×克⁻¹。小鼠脑、脊髓以及大鼠脊髓中色胺的周转率和半衰期估计分别为0.14纳摩尔×克⁻¹×小时⁻¹和0.9分钟；0.054纳摩尔×克⁻¹×小时⁻¹和1.5分钟；0.04纳摩尔×克⁻¹×小时⁻¹和1.6分钟。芳香族L - 氨基酸脱羧酶抑制剂NSD 1034和NSD 1055可降低对照组和经优降宁预处理动物体内色胺的合成。色氨酸可提高小鼠纹状体色胺和5 - 羟色胺以及脑干5 - 羟吲哚乙酸的浓度。对氯苯丙氨酸可减少5 - 羟色胺和5 - 羟吲哚乙酸的形成，但不改变色胺的形成。