DL-2-苯基[6-乙氧基苯并噻唑基-(2)-硫代]丙酸（EMD 34853）对仓鼠胆结石形成的影响。
Influence of DL-2-phenyl[6-ethoxybenzothiazolyl-(2)-thio]propionic acid (EMD 34853) on gallstone formation in hamsters.
作者信息
Kritchevsky D, Klurfeld D M
出版信息
Pharmacol Res Commun. 1984 Feb;16(2):111-5. doi: 10.1016/s0031-6989(84)80085-5.
PMID:6504964
Abstract
The effects of two levels (50 and 167 mg/kg) of a new hypocholesterolemic drug (EMD 34853) on gallstone formation in hamsters were investigated. Lithogenicity was inhibited by 28-45%. Levels of biliary lipids (cholesterol, phospholipid, bile acids) were reduced in the drug-treated animals.
摘要
研究了一种新型降胆固醇药物（EMD 34853）的两个剂量水平（50和167毫克/千克）对仓鼠胆结石形成的影响。结石形成能力受到28%-45%的抑制。药物治疗组动物的胆汁脂质（胆固醇、磷脂、胆汁酸）水平降低。
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