Zukowska-Grojec Z, Pamnani M, Feuerstein G
Clin Exp Hypertens A. 1984;6(9):1575-90. doi: 10.3109/10641968409044070.
Leukotriene D4 (LTD4), a constituent of slow-reacting substance of anaphylaxis (SRS-A), elicits a pressor response followed by prolonged hypotension in spontaneously hypertensive (SHR) but not in Wistar-Kyoto (WKY) rats. In order to investigate whether the depressor response to LTD4 in SHR rats is related to hypertension itself, we have studied the cardiovascular and sympathetic effects of LTD4 in 1-kidney, 1-clip hypertensive rats and 1-kidney, normotensive rats. In all groups of conscious rats, intra-arterial administration of LTD4 (0.2-20 micrograms/kg) caused dose-dependent pressor responses of similar degree except in WKY rats, which responded less. Only SHR rats developed a significant and progressive hypotension (-58 +/- 5 mm Hg) following pressor phase. In all but WKY rats, the response phase was attended by an increase in plasma levels of norepinephrine and epinephrine. Only SHR rats showed marked and persistent hemoconcentration following pressor effect. Thus, depressor response of SHR rats to systemic administration of LTD4 does not appear to be merely due to the magnitude of blood pressure elevation and may in part result from microcirculatory changes not present in other hypertensive rats.
白三烯D4（LTD4）是过敏反应慢反应物质（SRS-A）的一种成分，在自发性高血压（SHR）大鼠中可引发升压反应，随后出现长时间的低血压，但在Wistar-Kyoto（WKY）大鼠中则不会。为了研究SHR大鼠对LTD4的降压反应是否与高血压本身有关，我们研究了LTD4对1肾1夹高血压大鼠和1肾正常血压大鼠的心血管及交感神经效应。在所有清醒大鼠组中，除WKY大鼠反应较小外，动脉内给予LTD4（0.2 - 20微克/千克）均引起相似程度的剂量依赖性升压反应。只有SHR大鼠在升压期后出现显著且逐渐加重的低血压（-58±5毫米汞柱）。除WKY大鼠外，在所有大鼠中，反应期均伴有去甲肾上腺素和肾上腺素血浆水平升高。只有SHR大鼠在升压效应后出现明显且持续的血液浓缩。因此，SHR大鼠对全身给予LTD4的降压反应似乎不仅仅是由于血压升高的幅度，可能部分是由于其他高血压大鼠不存在的微循环变化所致。
