乙肝病毒标志物与海洛因作为吸毒者肝损伤原因之间的关系。
Relationship between HBV markers and heroin as a cause of liver injury in drug addicts.
作者信息
Vandelli C, Piaggi V, Battilani R, Cariani E, Sirotti M A
出版信息
Drug Alcohol Depend. 1984 Oct;14(2):129-33. doi: 10.1016/0376-8716(84)90038-3.
Fifty liver biopsies from heroin addicts on methadone maintenance were studied for histological features. The relationship between hepatic damage, HBV markers and the length of drug abuse was analysed. Infiltration was found in 95.6% of hepatitis B surface antigen (HBsAg) positive patients and in 50% of hepatitis B surface antibody (HBsAb) positive and HBV negative patients. The length of drug abuse showed a strong direct correlation with vacuolar degeneration (P less than 0.001) and an inverse correlation with fibrosis (P less than 0.05).
对50例接受美沙酮维持治疗的海洛因成瘾者的肝脏活检组织进行了组织学特征研究。分析了肝损伤、乙肝标志物与药物滥用时长之间的关系。在乙肝表面抗原（HBsAg）阳性患者中，95.6%存在浸润，在乙肝表面抗体（HBsAb）阳性且乙肝病毒（HBV）阴性的患者中，50%存在浸润。药物滥用时长与空泡变性呈强正相关（P<0.001），与纤维化呈负相关（P<0.05）。
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