作为神经肌肉阻滞剂的咪唑并吡啶鎓衍生物的合成与药理评价
Synthesis and pharmacological evaluation of imidazopyridinium derivatives as neuromuscular blocking agents.
作者信息
Bellani P, Clavenna G, Sosio A
出版信息
Farmaco Sci. 1984 Oct;39(10):846-62.
PMID:6510519
Abstract
A series of new imidazo[1,2-a]pyridinium derivatives have been prepared and studied as neuromuscular blocking agents in rats. These new substances are structurally related to fazadinium whose heterocyclic moieties were retained. All the new synthetized compounds are endowed with competitive neuromuscular blocking activity both in vitro and in vivo. Some were found to be equieffective with fazadinium with similar cardiovascular effects while some others possess more favorable therapeutic indexes.
摘要
已经制备了一系列新的咪唑并[1,2 - a]吡啶鎓衍生物，并在大鼠中作为神经肌肉阻滞剂进行了研究。这些新物质在结构上与法扎溴铵相关，其杂环部分得以保留。所有新合成的化合物在体外和体内均具有竞争性神经肌肉阻滞活性。发现一些化合物与法扎溴铵等效，具有相似的心血管效应，而其他一些化合物则具有更有利的治疗指数。
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