估计MN和Ss基因座的重组频率。

Estimating the recombination frequency for the MN and the Ss loci.

作者信息

Spence M A, Field L L, Marazita M L, Joseph J, Sparkes M, Crist M, Crandall B F, Anderson C E, Bateman J B, Rotter J I

出版信息

Hum Hered. 1984;34(6):343-7. doi: 10.1159/000153494.

Abstract

Linkage analysis of 146 informative families for MN and Ss resulted in an estimate of the recombination frequency greater than previously reported. Our total is 7 recombinant children out of 467 individuals, including 1 confirmed recombinant (retested and HLA-compatible) and 6 not verified. The 95% confidence interval of our estimate of recombination is 0.0033-0.0167. Our results are compared with two earlier studies.

摘要

对146个提供信息的家庭进行MN和Ss基因座的连锁分析，结果显示重组频率的估计值高于先前报道。在467个个体中，我们总共发现了7个重组子，其中包括1个经重新检测且HLA匹配的确认重组子和6个未经验证的重组子。我们对重组率估计的95%置信区间为0.0033 - 0.0167。我们将结果与两项早期研究进行了比较。