Kleinsasser O K, Glanz H
Laryngol Rhinol Otol (Stuttg). 1978 Mar;57(3):225-34.
Report on 5 cases of so called carcinosarcomas of the larynx and hypopharynx and review of literature. These polypoid tumors have a small epidermoid carcinomatous part and a major part with sarcoma like appearance. The sarcomatoid tissue resembles to fibrosarcomas or some undifferentiated pleomorphic sarcoma. Observations of a gradual transition from the epithelial tumor cells to cells with a mesodermal appearance show that these tumors are varieties of squamous cell carcinomas (spindle cell or pleomorphic variety) and not "combination"--or "collision-tumors", "carcinosarcomas" or "seudosarcomas". These tumors appear in the larynx predominantly in man, at the same sites and in the same ageclasses as common squamous cell cancers and are not less malignant. The sarcomatoid tissue can arise at the beginning of the disease or at a later stage it can appear or disappear after operation or irradiation. The reason for this change of cellular structure is unknown.
喉及下咽所谓癌肉瘤5例报告并文献复习。这些息肉样肿瘤有一小部分为表皮样癌组织，大部分呈肉瘤样外观。肉瘤样组织类似纤维肉瘤或某些未分化的多形性肉瘤。观察到上皮肿瘤细胞逐渐过渡为具有中胚层外观的细胞，表明这些肿瘤是鳞状细胞癌的变种（梭形细胞或多形性变种），而非“混合性”——或“碰撞瘤”、“癌肉瘤”或“假肉瘤”。这些肿瘤主要发生于男性喉部，与常见鳞状细胞癌的发病部位及年龄组相同，恶性程度也不低。肉瘤样组织可在疾病初期出现，或在后期出现，也可在手术或放疗后出现或消失。细胞结构发生这种变化的原因尚不清楚。
