内毒素及经辐射解毒的内毒素对大鼠血清甲状腺素（T4）水平及其甲状腺对外源性促甲状腺激素（TSH）反应的影响。
The effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH.
作者信息
Bertók L, Nagy S U
出版信息
Immunopharmacology. 1984 Dec;8(3-4):143-6. doi: 10.1016/0162-3109(84)90018-3.
PMID:6519960
Abstract
We have demonstrated that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum T4 level of rats and inhibits the T4 response given to exogenous thyroid stimulating hormone (TSH), the radio-detoxified (60Co-gamma, 150 kGy) endotoxin preparation does not inhibit the response to exogenous TSH and decreases serum T4 level to a lesser extent than untreated endotoxin.
摘要
我们已经证明，虽然亲本（有毒）内毒素的致休克剂量会显著降低大鼠的血清T4水平，并抑制对外源性促甲状腺激素（TSH）的T4反应，但经辐射解毒（60Co-γ，150 kGy）的内毒素制剂不会抑制对外源性TSH的反应，且血清T4水平降低的程度比未处理的内毒素小。
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