Belik J, Wagerle L C, Delivoria-Papadopoulos M
Pediatr Res. 1984 Dec;18(12):1305-8. doi: 10.1203/00006450-198412000-00017.
The purpose of this study was to evaluate cerebral blood flow and metabolism following pancuronium bromide paralysis in healthy newborn lambs. Cerebral blood flow and cerebral metabolic rate for O2 and glucose were measured along with blood pressure and blood gases before and again at 15 and 60 min following pancuronium paralysis in seven newborn lambs. Pancuronium bromide paralysis had no effect on any of these parameters either at 15 or 60 min of paralysis. Total cerebral blood flow, cerebral metabolic rate for O2, and cerebral metabolic rate for glucose were 87 +/- 6 ml/min/100 g, 258 +/- 10 mumol O2/min/100 g, and 53 +/- 10 mmol glucose/min/100 g, respectively. Neither was any change in regional cerebral blood flow noted. In spite of being connected immediately to the ventilator, however, some animals experienced a transient increase (average = 32%) in blood pressure, that was not associated with an increase in end tidal CO2. The data suggest that pancuronium paralysis in healthy awake newborn lambs does not lead to any alteration in cerebral blood flow or metabolism.
本研究的目的是评估健康新生羔羊在泮库溴铵麻痹后的脑血流量和代谢情况。在7只新生羔羊接受泮库溴铵麻痹前及麻痹后15分钟和60分钟，测量脑血流量、脑氧代谢率和脑葡萄糖代谢率，同时测量血压和血气。泮库溴铵麻痹在麻痹后15分钟或60分钟时对这些参数均无影响。脑总血流量、脑氧代谢率和脑葡萄糖代谢率分别为87±6毫升/分钟/100克、258±10微摩尔氧/分钟/100克和53±10毫摩尔葡萄糖/分钟/100克。也未观察到局部脑血流量有任何变化。然而，尽管立即连接到呼吸机，但一些动物的血压出现短暂升高（平均升高32%），这与呼气末二氧化碳升高无关。数据表明，健康清醒新生羔羊的泮库溴铵麻痹不会导致脑血流量或代谢的任何改变。
