Greer G J, Anuar H
Southeast Asian J Trop Med Public Health. 1984 Sep;15(3):303-12.
Using ELISA and COPT diagnostic tests, serological evidence of Malaysian schistosomiasis was discovered among Orang Asli populations from three areas in Peninsular Malaysia. Serum samples collected in 1975 indicated an ELISA-positive prevalence of 25% and a COPT prevalence of 11% from Pos Iskandar, Pahang and an ELISA prevalence of 13% and a COPT of 4% from Bukit Lanjan, Selangor. Resurveys at these site in 1982-1984 showed a continued presence of serological positive individuals but prevalence rates were markedly lower: 7% and 1% for ELISA and 4% and 2% for COPT at Pos Iskandar and Bukit Lanjan respectively. Snail hosts were not found at either site. The source of infection for persons living in these lowland areas remains unknown. In a third area, Kuala Tahan, Pahang, located in the foothills of the central mountain range, foci of transmission have been found near to Orang Asli settlements. The serological prevalence rate among Negrito Orang Asli in that study area was 9% for ELISA and 4% for COPT. Thirty-three of 36 COPT-positive sera produced vacuolated bleb precipates and in 31 these were the only reactions seen. The high percentage of positives producing only these precipates suggests that among Orang Asli schistosomiasis patients such reactions are not an indication of recently acquired infection as has been reported for schistosomiasis patients in the Philippines.
通过酶联免疫吸附测定（ELISA）和环卵沉淀试验（COPT）诊断检测，在马来西亚半岛三个地区的原住民（Orang Asli）人群中发现了马来西亚血吸虫病的血清学证据。1975年采集的血清样本显示，彭亨州波士依斯干达（Pos Iskandar）的ELISA阳性率为25%，COPT阳性率为11%；雪兰莪州武吉兰樟（Bukit Lanjan）的ELISA阳性率为13%，COPT阳性率为4%。1982 - 1984年在这些地点进行的重新调查显示，血清学阳性个体仍然存在，但患病率明显较低：波士依斯干达的ELISA和COPT患病率分别为7%和1%，武吉兰樟的分别为4%和2%。在这两个地点均未发现钉螺宿主。生活在这些低地地区的人的感染源仍然不明。在第三个地区，位于中央山脉山麓的彭亨州瓜拉大汉（Kuala Tahan），在原住民定居点附近发现了传播病灶。在该研究区域的尼格利陀原住民（Negrito Orang Asli）中，ELISA血清学患病率为9%，COPT为4%。36份COPT阳性血清中有33份产生了空泡泡状沉淀，其中31份是唯一可见的反应。仅产生这些沉淀的阳性比例很高，这表明在原住民血吸虫病患者中，这种反应并不像菲律宾血吸虫病患者那样表明是近期获得的感染。
