采食对马口服苯基丁氮酮、甲氧苄啶和磺胺嘧啶代谢命运的影响。
Effect of feeding on the fate of orally administered phenylbutazone, trimethoprim and sulphadiazine in the horse.
作者信息
Bogan J A, Galbraith A, Baxter P, Ali N M, Marriner S E
出版信息
Vet Rec. 1984 Dec 8;115(23):599-600. doi: 10.1136/vr.115.23.599.
PMID:6523691
Abstract
Phenylbutazone, sulphadiazine and trimethoprim were administered to three horses on two occasions, recently fed and unfed, and the effect of feeding on the pharmacokinetics of the three drugs assessed. The mean peak concentrations of phenylbutazone and trimethoprim were reduced by feeding by 34 and 75 per cent, respectively. The pharmacokinetics of sulphadiazine were not significantly affected.
摘要
分别在最近进食后和未进食时，给3匹马两次服用保泰松、磺胺嘧啶和甲氧苄啶，并评估进食对这三种药物药代动力学的影响。进食使保泰松和甲氧苄啶的平均峰值浓度分别降低了34%和75%。磺胺嘧啶的药代动力学未受到显著影响。
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