Platt D, Mühlberg W, Rieck W, Horn H J, Schmitt-Rüth R
Z Gerontol. 1984 Sep-Oct;17(5):246-50.
The present pharmacokinetic study of a drug used in geriatric patients with multiple diseases reveals that the half-life in the elderly was extended for about three times as long as in the corresponding control group. There are significant positive as well as negative correlations between the kinetic data and routine parameters of the metabolism. These statistical correlations should be controlled by experimental studies.
一项针对患有多种疾病的老年患者使用的药物的药代动力学研究表明,老年人的半衰期延长至相应对照组的约三倍。动力学数据与代谢常规参数之间存在显著的正相关和负相关。这些统计相关性应由实验研究来控制。