Herrmann R, Manegold C, Schroeder M, Tigges F J, Bartsch H, Jungi F, Fritze D
Cancer Treat Rep. 1984 Oct;68(10):1279-81.
Methotrexate and 5-FU were given sequentially with a 7-hour interval to 43 evaluable patients with heavily pretreated metastatic breast cancer. Partial remissions were seen in 12 patients (28%), indicating efficacy of this regimen in patients resistant to the conventional simultaneous application of these drugs.