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巴西巴伊亚州萨尔瓦多一家综合医院的葡萄糖-6-磷酸脱氢酶缺乏症(作者译)

[Glucose-6-phosphate dehydrogenase deficiency in a general hospital of Salvador, Bahia, Brazil (author's transl)].

作者信息

Azevêdo W C, Silva M L, Grassi M C, Azevêdo E S

出版信息

Rev Bras Pesqui Med Biol. 1978 May;11(1):49-52.

PMID:653016
Abstract

Eight hundreds and fifteen patients of the Prof. Edgard Santos Hospital, Salvador, Bahia, were studied for G6PD deficiency by the spot test. The frequencies of deficients were 11,39% for the blacks, 7,85% for the dark mulattoes and 6,98% for the medium mulattoes. There was no difference in the percentage of deficients between out patients and patients in the wards. Also, there was no difference in the means for hematocrit, hemoglobin, frequency of hospitalization and type of disease between patients with the deficiency and the control patients. However, a past history for jaundice was significantly more frequent among the deficient patients (22,22%) than among the control patients (12,76%) (x 2(1) = 4,43; p less than 0,03). These results suggest that, in Northeastern Brazil, G6PD deficiency is not severe enough to require hospitalization but is able to cause clinically detectable jaundice.

摘要

对巴伊亚州萨尔瓦多市埃德加德·桑托斯教授医院的815名患者进行了斑点试验,以研究葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症。黑人患者中缺乏症的发生率为11.39%,深肤色混血儿为7.85%,中等肤色混血儿为6.98%。门诊患者和病房患者中缺乏症患者的百分比没有差异。此外,缺乏症患者和对照患者在血细胞比容、血红蛋白、住院频率和疾病类型的平均值方面也没有差异。然而,有黄疸既往史的缺乏症患者(22.22%)明显比对照患者(12.76%)更常见(x²(1)=4.43;p<0.03)。这些结果表明,在巴西东北部,G6PD缺乏症的严重程度不足以需要住院治疗,但能够导致临床可检测到的黄疸。

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