采用冷滤过法去除冷球蛋白治疗冷球蛋白血症

Cryoglobulin removal with cryofiltration in the treatment of cryoglobulinemia.

作者信息

Abe Y, Sakamoto H, Matsugane T, Okabe K, Takaoka T, Blasutig E, Smith J W, Malchesky P S, Nose Y

出版信息

Trans Am Soc Artif Intern Organs. 1984;30:289-94.

Abstract

The technique of cryofiltration has been applied in the treatment of cryoglobulinemia. Good clinical improvement has been demonstrated accompanied by decreases of cryoglobulin levels. Three treatments in a week produced transient improvement of clinical symptoms and reduction of cryoglobulin levels. Follow-up treatments performed at adequate frequency and volume processed maintained relief of symptoms and serologic improvement. The cryofilter demonstrates good selectivity for cryoglobulin removal in cryogel, confirmed by electrophoretic analysis of both the cryogel filtrate from the cryofilter used clinically. Plasma cryofiltration appears to be a safe alternative to plasma exchange, requiring no replacement fluids.

摘要

冷滤过技术已应用于冷球蛋白血症的治疗。临床改善良好，同时冷球蛋白水平下降。每周进行三次治疗可使临床症状暂时改善，冷球蛋白水平降低。以适当的频率和容量进行后续治疗可维持症状缓解和血清学改善。冷滤器对冷凝胶中的冷球蛋白去除具有良好的选择性，这在临床上使用的冷滤器的冷凝胶滤液的电泳分析中得到了证实。血浆冷滤过似乎是血浆置换的一种安全替代方法，无需置换液。