家族性阿尔茨海默病的系谱研究。

Pedigree study of familial Alzheimer disease.

作者信息

Powell D, Folstein M F

出版信息

J Neurogenet. 1984 Apr;1(2):189-97. doi: 10.3109/01677068409107085.

Abstract

Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

摘要

在一家痴呆症诊所确定了21个患有家族性阿尔茨海默病的家庭，并通过多次家庭访谈进行评估。回顾了8例尸检情况。发病年龄从25岁到85岁不等。7个家系显示出三代遗传的证据。4个可评估系谱的创始者的父亲年龄高于对照组。