大鼠、豚鼠和猪体内六氯酚的经皮吸收

Percutaneous absorption of hexachlorophene in rats, guinea pigs and pigs.

作者信息

Chow C, Chow A Y, Downie R H, Buttar H S

出版信息

Toxicology. 1978 Feb;9(1-2):147-54. doi: 10.1016/0300-483x(78)90039-2.

Abstract

A comparative study of the percutaneous absorption of hexachlorophene (HCP) was undertaken in rats, guinea pigs and pigs. [14C]Hexachlorophene ([14C]HCP) was applied evenly over the shaved back of the animals at a dose of 40 microgram/cm2 skin surface. Urine and feces were collected at 24-h intervals for 5 days from animals kept in metabolism cages. Different methods were used for quantitating the percutaneous absorption of HCP. This study showed that skin permeability to HCP decreased in the following order: rat, guinea pig and pig. The permeability characteristics of the pig skin to topically applied HCP were comparable to the published human data. We suggest that pig may be a suitable animal model for studying the percutaneous absorption of antimicrobial drugs.

摘要

在大鼠、豚鼠和猪身上进行了六氯酚（HCP）经皮吸收的比较研究。将[14C]六氯酚（[14C]HCP）以40微克/平方厘米皮肤表面的剂量均匀涂抹在动物剃毛的背部。将动物置于代谢笼中，每隔24小时收集尿液和粪便，持续5天。采用不同方法定量HCP的经皮吸收。该研究表明，皮肤对HCP的通透性按以下顺序降低：大鼠、豚鼠和猪。猪皮肤对局部应用HCP的通透性特征与已发表的人体数据相当。我们认为猪可能是研究抗菌药物经皮吸收的合适动物模型。