Claussen C F, Bergmann J, Bertora G, Claussen E
Arzneimittelforschung. 1984;34(12):1791-8.
This paper presents a study by means of a modern neurotological technique for investigating the action and the site of action of an antivertiginous drug. The sensory motor tests are able to discriminate the sites of the lesions in the equilibrium regulating system, i.e., peripheral vestibular system, lower brainstem regulating system, upper brainstem nystagmus generating system and supratentorial system. Acoustic brainstem evoked potentials add information. A sample of 40 vertigo and nausea patients was treated by a combined drug, containing cocculus D4 210 mg, conium D3 30 mg, ambra D6 30 mg, mineral oil D8 30 mg (Vertigo-heel). The patients received 3 tablets 3 times per day during 14 days. An initial investigation was performed just before starting the treatment. A second directly followed the therapy. By subjective self-rating 57.5% of the patients reported on an improvement after the intake of Vertigoheel. Statistical evaluations showed that the different vertigo and nausea symptoms as well as the trigger mechanisms of vertigo and nausea (i.e. getting up, turning the head or gazing aside), highly significantly improved due to the therapy. The objective sensory motor tests showed a highly significant improvement in the monaural caloric butterfly chart as well as in the vestibulospinal head and body sway. The site of the action of Vertigoheel is in the brainstem and the Medulla oblongata, especially the middle longitudinal fascicle (MLF). The localisation in this area can be stressed by the investigation with acoustically brainstem evoked potentials (ABEP).(ABSTRACT TRUNCATED AT 250 WORDS)
本文介绍了一项利用现代神经耳科学技术进行的研究,旨在探究一种抗眩晕药物的作用及作用部位。感觉运动测试能够区分平衡调节系统中病变的部位,即外周前庭系统、低位脑干调节系统、高位脑干眼震产生系统和幕上系统。脑干听觉诱发电位可提供更多信息。选取40例眩晕和恶心患者作为样本,用一种复方药物进行治疗,该药物含有木防己D4 210毫克、毒参D3 30毫克、琥珀D6 30毫克、矿物油D8 30毫克(眩晕停)。患者在14天内每天服用3次,每次3片。在开始治疗前进行了初步检查,治疗结束后紧接着进行了第二次检查。通过主观自评,57.5%的患者报告服用眩晕停后症状有所改善。统计评估表明,不同的眩晕和恶心症状以及眩晕和恶心的触发机制(即起床、转头或向一侧凝视),经治疗后有极显著改善。客观感觉运动测试表明,单耳冷热试验蝴蝶图以及前庭脊髓头部和身体摆动均有极显著改善。眩晕停的作用部位在脑干和延髓,尤其是内侧纵束(MLF)。通过脑干听觉诱发电位(ABEP)检查可突出该区域的定位。(摘要截选至250字)