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生物标准稳定性加速降解试验的设计与分析II. 用于数据分析的灵活计算机程序

Design and analysis of accelerated degradation tests for the stability of biological standards II. A flexible computer program for data analysis.

作者信息

Kirkwood T B, Tydeman M S

出版信息

J Biol Stand. 1984;12(2):207-14. doi: 10.1016/s0092-1157(84)80055-4.

Abstract

The accelerated degradation test is commonly used to predict the stability of a biological standard during long-term storage at low temperature. A flexible computer program is described which has been written to analyse degradation test results by the method of maximum likelihood. In addition to predicting the degradation rate at low temperature, the program furnishes estimates of statistical precision and it carried out a test of goodness of fit of the data to the assumed Arrhenius equation model.

摘要

加速降解试验通常用于预测生物标准品在低温下长期储存期间的稳定性。本文描述了一个灵活的计算机程序,该程序通过最大似然法编写,用于分析降解试验结果。除了预测低温下的降解速率外,该程序还提供统计精度估计,并对数据与假定的阿伦尼乌斯方程模型的拟合优度进行检验。

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