精神药物对钒酸盐还原的催化作用。
Catalysis of the reduction of vanadate by psychotropic drugs.
作者信息
Naylor G J, Smith A H, Trotter P
出版信息
Neuropharmacology. 1983 May;22(5):653-6. doi: 10.1016/0028-3908(83)90158-2.
PMID:6553764
Abstract
It has been suggested that vanadium may be of aetiological importance in manic depressive psychosis. Therefore, the ability of psychotropic drugs to catalyze the reduction of vanadate ion by reduced nicotinamide adenine dinucleotide (NADH) was investigated. The most active drug was methylene blue but all the phenothiazines and all the monoamine oxidase inhibitors tested showed catalytic activity. A large number of drugs showed no catalytic activity, eg. tricyclic antidepressants and benzodiazepines.
摘要
有人提出钒在躁狂抑郁症中可能具有病因学意义。因此，研究了精神药物催化还原型烟酰胺腺嘌呤二核苷酸（NADH）还原钒酸根离子的能力。活性最高的药物是亚甲蓝，但所有测试的吩噻嗪类药物和所有单胺氧化酶抑制剂均显示出催化活性。大量药物没有催化活性，例如三环类抗抑郁药和苯二氮䓬类药物。
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