培养的人肿瘤细胞中岩藻糖向脂质部分的细胞群体密度依赖性掺入丧失。
Loss of cell-population-density-dependent incorporation of fucose into the lipid fraction of cultured human tumour cells.
作者信息
Gacto M
出版信息
Biochem J. 1978 Apr 15;172(1):181-4. doi: 10.1042/bj1720181.
Abstract
The incorporation of radioactively labelled fucose into the lipid fraction of cultured normal human cells and several human tumour-cell lines was examined as a function of the cell population density. Normal cells exhibited a density-dependent pattern of incorporation, whereas in tumour cells the radioactivity incorporated was independent of the cell population density. An exception was found among the tumour cells, which suggests a possible correlation between the loss of this marker and the ability to produce tumours.
摘要
研究了放射性标记的岩藻糖掺入培养的正常人细胞和几种人肿瘤细胞系脂质部分的情况，并将其作为细胞群体密度的函数。正常细胞呈现出密度依赖性的掺入模式，而在肿瘤细胞中，掺入的放射性与细胞群体密度无关。在肿瘤细胞中发现了一个例外情况，这表明该标记物的丧失与产生肿瘤的能力之间可能存在关联。
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