Sharr M M, Garfield J S
Br Med J. 1978 Jun 10;1(6126):1535-7. doi: 10.1136/bmj.1.6126.1535.
Of 223 patients with intracranial metastases, 161 underwent removal of a presumed solitary lesion and 29 were treated by burr-hole biopsy. Results of radical surgery were better than those of biopsy alone in terms of survival. Quality and duration of survival were poorer in patients who had infratentorial metastases removed than in those who underwent surgery for supratentorial metastases. In this second group only patients with breast cancer benefited from surgery, though a few women with bronchial carcinoma also did well. The interval removal of a primary tumour and development of intracranial symptoms did not influence outcome. Evidence of a previous primary tumour should not lead to the assumption that intracranial symptoms are caused by a metastasis.
在223例颅内转移瘤患者中，161例接受了疑似孤立性病灶切除术，29例接受了钻孔活检。就生存率而言，根治性手术的结果优于单纯活检。幕下转移瘤切除患者的生存质量和生存期比幕上转移瘤手术患者更差。在第二组中，只有乳腺癌患者从手术中获益，不过少数支气管癌女性患者手术效果也较好。原发肿瘤切除与颅内症状出现之间的间隔时间不影响预后。既往有原发肿瘤的证据不应导致颅内症状由转移瘤引起的假设。
