大剂量阿糖胞苷治疗引起的急性小脑功能障碍。

Acute cerebellar dysfunction with high-dose ARA-C therapy.

作者信息

Salinsky M C, Levine R L, Aubuchon J P, Schutta H S

出版信息

Cancer. 1983 Feb 1;51(3):426-9. doi: 10.1002/1097-0142(19830201)51:3<426::aid-cncr2820510312>3.0.co;2-s.

DOI:10.1002/1097-0142(19830201)51:3<426::aid-cncr2820510312>3.0.co;2-s

Abstract

The authors report a patient with clinical and morphologic evidence of acute cerebellar toxicity after receiving high-dose cytosine arabinoside (ARA-C) (3000 mg/m2/12 hours) for refractory AML. Damage of Purkinje cells and dentate nucleus was demonstrated. Reversible cerebellar toxicity has previously been noted in patients on an identical regimen. Signs of cerebellar dysfunction mandate immediate cessation of high-dose ARA-C therapy.

摘要

作者报告了一名难治性急性髓系白血病患者，在接受大剂量阿糖胞苷（ARA-C）（3000mg/m²/12小时）治疗后出现急性小脑毒性的临床和形态学证据。已证实浦肯野细胞和齿状核受损。之前在接受相同治疗方案的患者中已注意到可逆性小脑毒性。小脑功能障碍的体征要求立即停止大剂量ARA-C治疗。