Newman R A
Clin Chim Acta. 1978 Jun;86(2):195-200. doi: 10.1016/0009-8981(78)90133-x.
The application of flameless atomic absorption spectrophotometry to the quantitation of gallium in urine, serum and tissues is described. The method can be used to detect gallium concentrations as low as 100--200 ppb in fluids and tissues. Significant interference with the gallium atomization signal was caused by CaCl2; however, the interference could be completely prevented by using the chelating agent EDTA. This method makes feasible the quantitative determination of the pharmacokinetic parameters of gallium administration as an anticancer drug in animals and humans.
本文描述了无火焰原子吸收分光光度法在尿液、血清和组织中镓定量分析中的应用。该方法可用于检测体液和组织中低至100 - 200 ppb的镓浓度。CaCl2对镓原子化信号有显著干扰；然而，使用螯合剂EDTA可完全防止这种干扰。该方法使定量测定镓作为抗癌药物在动物和人体中的药代动力学参数成为可能。
