Kune G A, Hunt R
Aust N Z J Surg. 1983 Jun;53(3):249-51. doi: 10.1111/j.1445-2197.1983.tb02437.x.
In four groups of 25 patients in whom perioperative prophylactic antibiotics were not used, the wound infection rates after partial gastrectomy were 40% in gastric cancer, 44% in chronic gastric ulcer, 24% in chronic duodenal ulcer and after trunkal vagotomy and pyloroplasty, the wound infection rate was 12%. In gastric cancer and chronic gastric ulcer, most wound infections were caused by enterobacteria, while in chronic duodenal ulcer almost all infections were caused by Staphylococcus aureus. Appropriate short-term perioperative prophylactic antibiotic use is likely to decrease wound sepsis rate in patients who have a gastric resection in the presence of gastric cancer or gastric ulcer.
在四组每组25例未使用围手术期预防性抗生素的患者中,部分胃切除术后的伤口感染率在胃癌患者中为40%,在慢性胃溃疡患者中为44%,在慢性十二指肠溃疡患者中为24%,而行迷走神经干切断术和幽门成形术后的伤口感染率为12%。在胃癌和慢性胃溃疡患者中,大多数伤口感染由肠杆菌引起,而在慢性十二指肠溃疡患者中,几乎所有感染均由金黄色葡萄球菌引起。对于存在胃癌或胃溃疡而行胃切除术的患者,适当短期使用围手术期预防性抗生素可能会降低伤口脓毒症发生率。