成人型慢性粒细胞白血病中的幼稚特征。

Juvenile features in adult-type chronic granulocytic leukemia.

作者信息

Gay J C, Dessypris E N, Roloff J S, Lukens J N

出版信息

Am J Hematol. 1984 Jan;16(1):99-102. doi: 10.1002/ajh.2830160114.

Abstract

Philadelphia chromosome (Ph1) positive, or "adult-type," chronic granulocytic leukemia (CGL) differs in many clinical and laboratory aspects from PH1-negative, or "juvenile," CGL. Because of these differences, the disorders have been considered two distinct disease entities. We present a child with Ph1-positive CGL whose disease has several features more characteristic of the Ph1-negative syndrome. This case demonstrates that the chromosomal anomaly in CGL is not always predictive of phenotypic expression in this disease.

摘要

费城染色体（Ph1）阳性，即“成人型”慢性粒细胞白血病（CGL），在许多临床和实验室方面与Ph1阴性，即“幼年型”CGL有所不同。由于这些差异，这两种疾病被视为两个不同的疾病实体。我们报告一名患有Ph1阳性CGL的儿童，其疾病具有一些更具Ph1阴性综合征特征的特点。该病例表明，CGL中的染色体异常并不总是能预测该疾病的表型表达。