脊髓5-羟色胺或去甲肾上腺素摄取抑制增强大鼠脊髓上吗啡的镇痛作用。

Spinal 5-HT or NA uptake inhibition potentiates supraspinal morphine antinociception in rats.

作者信息

Larsen J J, Arnt J

出版信息

Acta Pharmacol Toxicol (Copenh). 1984 Jan;54(1):72-5. doi: 10.1111/j.1600-0773.1984.tb01897.x.

DOI:10.1111/j.1600-0773.1984.tb01897.x

Abstract

Spinal injection of the specific uptake inhibitor of 5-hydroxytryptamine (5-HT), citalopram, or of noradrenaline (NA), desipramine, potentiated the antinociception following intracerebroventricular injection of morphine in rats tested on the hot plate. Combined spinal injection of citalopram and desipramine caused a synergistic potentiation. The unselective and less potent inhibitor of both 5-HT and NA uptake, amitriptyline, did not cause potentiation. The results support the suggested involvement of both 5-HT and NA pathways in supraspinal morphine antinociception.

摘要

在热板试验的大鼠中，脊髓注射5-羟色胺（5-HT）的特异性摄取抑制剂西酞普兰，或去甲肾上腺素（NA）的摄取抑制剂地昔帕明，可增强脑室内注射吗啡后的镇痛作用。联合脊髓注射西酞普兰和地昔帕明可产生协同增强作用。5-HT和NA摄取的非选择性且效力较弱的抑制剂阿米替林则不会产生增强作用。这些结果支持了5-HT和NA通路均参与脊髓上吗啡镇痛作用的观点。