用单克隆抗体791T/36对结肠直肠癌进行免疫闪烁显像

Immunoscintigraphy of colorectal carcinoma with monoclonal antibody 791T/36.

作者信息

Pimm M V, Armitage N C, Perkins A C, Hardcastle J D, Baldwin R W

出版信息

Behring Inst Mitt. 1984 May(74):80-6.

PMID:6591917

Abstract

A monoclonal antibody 791T/36 prepared against a human osteogenic sarcoma has been used to detect primary and metastatic colorectal carcinoma by external imaging of patients infused with 131I-labelled antibody. Positive images were obtained with 8/11 primary colon tumours, 5/12 rectal tumours and 14/15 secondary and recurrent tumours. Positive tumour localization of radiolabelled antibody was confirmed by imaging and radioactivity counts on resected specimens. None of five patients with benign colorectal disease showed positive images and only 2/12 other gastrointestinal cancers were detected.

摘要

一种针对人骨肉瘤制备的单克隆抗体791T/36，已被用于通过对注入131I标记抗体的患者进行体外成像来检测原发性和转移性结直肠癌。11例原发性结肠肿瘤中有8例、12例直肠肿瘤中有5例以及15例继发性和复发性肿瘤中有14例获得了阳性图像。通过对切除标本的成像和放射性计数证实了放射性标记抗体在肿瘤中的阳性定位。5例患有良性结直肠疾病的患者均未显示阳性图像，其他胃肠道癌症仅检测到12例中的2例。