Wienbeck M, Sperling T
Z Gastroenterol. 1984 Oct;22(10):580-5.
Controversy exists with respect to the motor effects of prostaglandins (PG) in the colon. We studied the actions of the prostaglandins F2 alpha and E2 on the spontaneous and stimulated contractions of the circular muscle of the cat colon in vitro. Both prostaglandins enhanced contractile activity. PG F2 alpha was more effective than PG E2, the ED50 were 4.2 X 10(-9) M and 2 X 10(-7) M, respectively. The prostaglandin antagonist 8 ethoxycarbonyl-5-methyl-10,11-dihydroxy-PG A1-ethyl-ester (HR 546) in a concentration of 10(-7) M shifted the ED50 of PG F2 alpha to the right by 1 log unit and unmasked motor stimulatory actions of low PG F2 alpha concentrations (10(-11) and 10(-10) M). The latter effect was atropine sensitive. In conclusion, PG F2 alpha and PG E2 stimulate contractions of the circular colon muscle at concentrations naturally occurring in the gut. It is conceivable that they play a role in the control of colonic motility, particularly in diseases like ulcerative colitis and Crohn's disease.
关于前列腺素（PG）对结肠的运动效应存在争议。我们在体外研究了前列腺素F2α和E2对猫结肠环形肌自发收缩和刺激收缩的作用。两种前列腺素均增强了收缩活性。PG F2α比PG E2更有效，其半数有效剂量（ED50）分别为4.2×10⁻⁹M和2×10⁻⁷M。浓度为10⁻⁷M的前列腺素拮抗剂8-乙氧羰基-5-甲基-10,11-二羟基-PG A1-乙酯（HR 546）使PG F2α的ED50向右移动1个对数单位，并揭示了低浓度PG F2α（10⁻¹¹和10⁻¹⁰M）的运动刺激作用。后一种效应对阿托品敏感。总之，PG F2α和PG E2在肠道中自然存在的浓度下刺激结肠环形肌收缩。可以想象，它们在结肠运动的控制中起作用，特别是在溃疡性结肠炎和克罗恩病等疾病中。
