O'Connor D T
J Hypertens Suppl. 1984 Dec;2(3):S147-50.
Chromogranin A, the major soluble protein costored and coreleased by exocytosis with catecholamines, has been purified to homogeneity from both bovine adrenomedullary and human phaeochromocytoma chromaffin granules. Each is an acidic monomeric protein. Radio-immunoassays have been established for both bovine and human chromogranin A; the assays detect chromogranin immunoreactivity in adrenergic tissues and subcellular fractions, as well as in serum or plasma. In human plasma, chromogranin immunoreactivity is moderately elevated (mean, 1.5-fold) in essential hypertension, and substantially elevated (mean, 12.5-fold) in subjects with phaeochromocytoma. Initial physiological and pharmacological studies suggest that plasma chromogranin A varies with the state of endogenous exocytotic sympathoadrenal activity, but the plasma chromogranin changes are modest and the ultimate source of the plasma immunoreactivity (e.g. adrenomedullary versus sympathetic neuronal) has not yet been determined.
嗜铬粒蛋白A是一种主要的可溶性蛋白，它与儿茶酚胺通过胞吐作用共同储存和释放，已从牛肾上腺髓质和人嗜铬细胞瘤嗜铬颗粒中纯化至同质。两者均为酸性单体蛋白。已经建立了针对牛和人嗜铬粒蛋白A的放射免疫测定法；这些测定法可检测肾上腺素能组织、亚细胞组分以及血清或血浆中的嗜铬粒蛋白免疫反应性。在人血浆中，嗜铬粒蛋白免疫反应性在原发性高血压中中度升高（平均为1.5倍），在嗜铬细胞瘤患者中大幅升高（平均为12.5倍）。初步的生理和药理学研究表明，血浆嗜铬粒蛋白A随内源性胞吐性交感肾上腺活动状态而变化，但血浆嗜铬粒蛋白的变化较小，血浆免疫反应性的最终来源（例如肾上腺髓质与交感神经元）尚未确定。
