Taber D S, Libshitz H I, Cohen M A
AJR Am J Roentgenol. 1983 Apr;140(4):753-8. doi: 10.2214/ajr.140.4.753.
Healing of Ewing sarcoma after therapy has a predictable radiographic appearance, eventually stabilizing and remaining constant in appearance. This study is based on 35 patients in whom adequate follow-up radiographs were available. The expected sequence was evident in 21 patients. Complete healing was evident in about 1 year. Failure to heal as expected or lytic change in healed bone indicated recurrent or refractory disease in 11 patients who developed distant metastases or clinical signs of recrudescence at the primary site. This complication was evident within months to 2 years of the initial treatment. In three patients, development of a new, primary, osteogenic sarcoma was heralded by disorganized tumor new bone in an osteoid matrix, evident only after several years of stability. These new osseous malignancies are probably treatment-related.
尤因肉瘤治疗后的愈合具有可预测的影像学表现，最终会稳定下来且外观保持不变。本研究基于35例有足够随访X光片的患者。21例患者呈现出预期的序列。约1年后可见完全愈合。11例患者未按预期愈合或愈合骨出现溶骨性改变，提示疾病复发或难治，这些患者出现了远处转移或原发部位复发的临床体征。这种并发症在初始治疗后的数月至2年内明显。在3例患者中，仅在数年稳定期后，类骨质基质中杂乱的肿瘤新骨预示着新的原发性骨肉瘤的发生。这些新的骨恶性肿瘤可能与治疗有关。
