类风湿滑膜中的γ T淋巴细胞

[T gamma lymphocytes in rheumatoid synovial membrane].

作者信息

Ishikawa H, Ugai K, Ohno O, Matsubara T, Yamasaki K, Sakata T, Hirohata K

出版信息

Nihon Seikeigeka Gakkai Zasshi. 1983 Mar;57(3):285-91.

Abstract

The proportion of T lymphocytes with receptors for the Fc portion of IgG (T gamma cells), revealed by mixed rosette assay, was determined in the synovial membrane and peripheral blood of 11 patients with rheumatoid arthritis. The percentage of T gamma cells in the lymphocytic infiltration of rheumatoid synovium was significantly lower than that found in peripheral blood (p less than 0.005). There was no significant difference between the percentage of T lymphocytes in the synovial tissue and that in peripheral blood. Depressed supressor activity of T lymphocytes in rheumatoid synovial membrane might lead B-lymphocytes to blastic transformation to the plasma cell series with consequent production of large amounts of immunoglobulins in the joint.

摘要

采用混合玫瑰花结试验测定了11例类风湿性关节炎患者滑膜和外周血中具有IgG Fc段受体的T淋巴细胞（Tγ细胞）比例。类风湿性滑膜炎淋巴细胞浸润中Tγ细胞的百分比显著低于外周血中的百分比（p<0.005）。滑膜组织中T淋巴细胞的百分比与外周血中的百分比无显著差异。类风湿性滑膜中T淋巴细胞抑制活性降低可能导致B淋巴细胞向浆细胞系的母细胞转化，从而在关节中产生大量免疫球蛋白。