B细胞受抑制的无菌裸鼠中的抗体依赖性细胞毒性（K）和自然杀伤（NK）
Antibody-dependent cellular cytotoxicity (K) and natural killing (NK) in B-suppressed germ-free nude rats.
作者信息
Chassoux D, Kolb J P, Bazin H, MacLennan I C
出版信息
Immunology. 1983 Nov;50(3):327-34.
The influence of the thymus and the possible requirement for surface immunoglobulin expression for the development of K and NK activity were assessed in rats. This species was chosen in preference to mice as they show good levels of K-cell activity. Studies were carried out in athymic (rnu/rnu) rats some of which were treated from birth with rabbit anti-rat IgM antibody to suppress B-cell development. The results indicate that normal levels of both K and NK activity develop in the spleens of 6-8-week-old athymic rats, which do not contain cells expressing surface membrane immunoglobulin. While K and NK cells show characteristics of the lymphoid lineage, neither the thymus nor surface membrane immunoglobulin expression appears to be required for development of normal levels of these cytolytic activities.
在大鼠中评估了胸腺的影响以及K细胞和NK细胞活性发育对表面免疫球蛋白表达的可能需求。之所以选择该物种而非小鼠，是因为它们表现出良好水平的K细胞活性。在无胸腺（rnu/rnu）大鼠中开展了研究，其中一些大鼠从出生起就用兔抗大鼠IgM抗体进行处理，以抑制B细胞发育。结果表明，在6-8周龄无胸腺大鼠的脾脏中可发育出正常水平的K细胞和NK细胞活性，这些大鼠的脾脏中不含有表达表面膜免疫球蛋白的细胞。虽然K细胞和NK细胞表现出淋巴谱系的特征，但正常水平的这些细胞溶解活性的发育似乎既不需要胸腺，也不需要表面膜免疫球蛋白表达。
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