Ishii Y, Odori T, Hamanaka D, Yokoyama A, Torizuka K
Gan No Rinsho. 1983 Aug;29(10):1181-5.
Tumor imaging by radiopharmaceuticals classified into two modalities; The one is a negative imaging, whereby a tumor is depicted as a non-functional cold spot. The other is a positive imaging on the use of tumor seeking agents. The detectability of the tumor as a cold spot has enhanced by introducing the emission computed tomography. A variety of effort to develop specific tumor seeking agents are in progress, by radio-labeling tumor specific antigen and its abnormal metabolic conditions using cyclotron produced radioactive metabolites as well as radiometal compounds.
放射性药物的肿瘤成像分为两种模式;一种是阴性成像,即肿瘤被描绘为无功能的冷区。另一种是使用肿瘤靶向剂的阳性成像。通过引入发射计算机断层扫描,作为冷区的肿瘤的可检测性得到了提高。通过使用回旋加速器产生的放射性代谢物以及放射性金属化合物对肿瘤特异性抗原及其异常代谢状况进行放射性标记,正在进行各种开发特异性肿瘤靶向剂的努力。