Nasrallah H A, Kuperman S, Hamra B J, McCalley-Whitters M
J Clin Psychiatry. 1983 Nov;44(11):407-9.
In a group of 55 chronic schizophrenic men aged 20-45 years, the mean ventricle to brain ratio (VBR) on computerized tomographic brain scan was significantly greater than in 27 matched control subjects. A clinical comparison was then conducted between the schizophrenic patients with VBRs above (N = 19) or below (N = 36) 2 SD from the control mean. No differences were found in age of onset, premorbid history, duration of illness, severity of illness, response to neuroleptic drug treatment, presence of positive or negative symptoms, substance abuse, or cognitive testing. However patients with VBRs greater than 2 SD above the mean were significantly older and had a significantly higher frequency of history of schizophrenia in a first-degree relative.
在一组年龄在20至45岁之间的55名慢性精神分裂症男性患者中，脑部计算机断层扫描显示的平均脑室与脑容积比（VBR）显著高于27名匹配的对照受试者。然后，对VBR高于（N = 19）或低于（N = 36）对照均值2个标准差的精神分裂症患者进行了临床比较。在发病年龄、病前史、病程、病情严重程度、对抗精神病药物治疗的反应、阳性或阴性症状的存在、药物滥用或认知测试方面均未发现差异。然而，VBR高于均值2个标准差的患者年龄显著更大，且一级亲属中有精神分裂症病史的频率显著更高。
