[核小体结构中DNA与组蛋白八聚体的包装模型]
[Model of the packing of DNA and histone octamer in the structure of the nucleosome].
作者信息
Khrapunov S N, Sivolob A V, Berdyshev G D
出版信息
Biofizika. 1983 Jul-Aug;28(4):573-8.
A model is proposed which describes the packing of polypeptide chains of histone molecules in the octamer (H3--H4--H2A--H2B)2, and interlocation of DNA and octamer in the nucleosome. DNA packing in the nucleosome is provided for by electrostatic interactions between DNA phosphates and cationic groups located on the globular part surface of histones octamer. The cationic groups of N- and C-end regions of the histone molecules (histones H3 and H4 in particular) additionally stabilize the nucleosome structure.
提出了一个模型，该模型描述了八聚体（H3--H4--H2A--H2B）2中组蛋白分子多肽链的堆积情况，以及DNA和八聚体在核小体中的相互位置。核小体中的DNA堆积是由DNA磷酸基团与位于组蛋白八聚体球状部分表面的阳离子基团之间的静电相互作用实现的。组蛋白分子N端和C端区域的阳离子基团（特别是组蛋白H3和H4）进一步稳定了核小体结构。
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