Marx G F, Kim Y I, Lin C C, Halevy S, Schulman H
Obstet Gynecol. 1978 Jun;51(6):695-8.
Postpartum uterine pressures were measured in healthy women with an intrauterine microballoon before, during, and after administration of different concentrations of halothane or enflurane. Arterial blood samples for anesthetic levels were obtained at intervals. Frequency and intensity of contractions diminished markedly when blood levels exceeded the equivalent of 1/2 MAC (minimum alveolar anesthetic concentration which produces immobility in one-half of subjects exposed to a noxious stimulus) of nonpregnant adults, but normal patterns returned promptly on lightening of anesthesia. Response to 10 mU of oxytocin was suppressed at blood levels corresponding to between 3/4 and 1 MAC of the agents. Halothane and enflurane exert equipotent dose-related reversible effects on the activity of the full-term pregnant human uterus.
在健康女性中，于给予不同浓度的氟烷或恩氟烷之前、期间及之后，使用宫内微球囊测量产后子宫压力。每隔一段时间采集动脉血样本以测定麻醉水平。当血液水平超过非妊娠成年人等效1/2 MAC（使一半暴露于有害刺激的受试者产生不动状态的最低肺泡麻醉浓度）时，宫缩的频率和强度显著降低，但麻醉减轻后正常模式迅速恢复。在对应于这些药物3/4至1 MAC的血液水平时，对10 mU缩宫素的反应受到抑制。氟烷和恩氟烷对足月妊娠人类子宫的活动具有等效的剂量相关可逆作用。
