神经16S乙酰胆碱酯酶可被肝素溶解。
Neural 16S acetylcholinesterase is solubilized by heparin.
作者信息
Torres J C, Behrens M I, Inestrosa N C
出版信息
Biochem J. 1983 Oct 1;215(1):201-4. doi: 10.1042/bj2150201.
Abstract
The effect of heparin, a sulphated glycosaminoglycan, on the solubilization of rat sciatic-nerve acetylcholinesterase (acetylcholine acetylhydrolase; AChE; EC 3.1.1.7) was studied. It was found that heparin solubilized esterase activity from ligated nerves. Sedimentation analysis revealed this activity to be mainly the 16S form. Chondroitin sulphate did not solubilize AChE activity, and protamine eliminated the solubilizing effect. Our results suggest the involvement of sulphated glycosaminoglycans in the intra-axonal localization and transport of 16S AChE.
摘要
研究了硫酸化糖胺聚糖肝素对大鼠坐骨神经乙酰胆碱酯酶（乙酰胆碱乙酰水解酶；AChE；EC 3.1.1.7）溶解作用的影响。发现肝素可溶解结扎神经中的酯酶活性。沉降分析表明该活性主要为16S形式。硫酸软骨素不能溶解AChE活性，而鱼精蛋白可消除这种溶解作用。我们的结果提示硫酸化糖胺聚糖参与了16S AChE在轴突内的定位和运输。
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