从人白血病细胞中分离出的C型致癌RNA病毒HL-23V对狨猴的致癌性，以及与1型猿猴肉瘤病毒（SSV-1/SSAV-1）的比较。

Oncogenicity in marmosets of HL-23V, a type C oncornavirus isolated from human leukemic cells, and comparison with simian sarcoma virus type 1 (SSV-1/SSAV-1).

作者信息

Bergholz C M, Wolfe L G, Deinhardt F, Thakkar B, Marczynska B

出版信息

J Natl Cancer Inst. 1977 Apr;58(4):1041-6. doi: 10.1093/jnci/58.4.1041.

DOI:10.1093/jnci/58.4.1041

Abstract

Type C virus produced by dog thymus cells (A7573) that were infected with virus (HL-23V), isolated from cultured leukocytes of an acute myelogenous leukemia patient, transformed marmoset and horse cells in vitro and induced virus-producing fibromas in marmosets. The tumors and transformed foci were indistinguishable morphologically from those induced by simian sarcoma virus, type 1 (SSV-1/SSAV-1). HL-23V was indistinguishable from SSV-1/SSAV-1 by immunofluorescence and neutralization tests, and the nontransforming virus associated with HL-23V completely inhibited SSV-1 focus induction in interference tests. Cell cultures established from a marmoset fibroma produced transforming and nontransforming virus biologically and antigenically indistinguishable from HL-23V and SSV-1/SSAV-1.

摘要

由感染了从一名急性髓性白血病患者培养的白细胞中分离出的病毒（HL - 23V）的犬胸腺细胞（A7573）产生的C型病毒，在体外转化了狨猴和马细胞，并在狨猴中诱导产生了产生病毒的纤维瘤。这些肿瘤和转化灶在形态上与由1型猿猴肉瘤病毒（SSV - 1/SSAV - 1）诱导的肿瘤和转化灶无法区分。通过免疫荧光和中和试验，HL - 23V与SSV - 1/SSAV - 1无法区分，并且在干扰试验中，与HL - 23V相关的非转化病毒完全抑制了SSV - 1灶的诱导。从狨猴纤维瘤建立的细胞培养物产生了在生物学和抗原性上与HL - 23V以及SSV - 1/SSAV - 1无法区分的转化和非转化病毒。